Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection
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STOMACH Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection
suggests that colesevelam may be beneficial for patients with diarrhoea who have undergone small bowel resection forCrohn’s disease. There are no other published data to support its role in bile salt induced diarrhoea. Colesevelam is reported to be 4–6 times as potent as traditional bile salt sequestrants, possibly due to its greaterbinding affinity for glycocholic acid. It is administe...
متن کاملHost gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection.
BACKGROUND AND AIMS We tested if host gastric Lewis antigens and the babA2 genotype of Helicobacter pylori correlated with clinicohistological outcome. METHODS We enrolled 188 dyspeptic patients (45 with duodenal ulcer, 45 with gastric ulcer, and 98 with chronic gastritis) with H pylori infection, proved by culture and gastric histology, reviewed by the updated Sydney system. Gastric expressi...
متن کاملInfluence of Lewis antigen expression by Helicobacter pylori on bacterial internalization by gastric epithelial cells.
The role of Helicobacter pylori lipopolysaccharide (LPS) Lewis antigens in infection is still not well known. We investigated the influence of Lewis antigen expression by H. pylori on its internalization by AGS cells and the epithelium of human gastric xenografts in nude mice using isogenic mutants in LPS biosynthetic genes. In vivo, colonization rates were unaffected by the change in H. pylori...
متن کاملHELICOBACTER PYLORI Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions
Background: Helicobacter pylori blood group antigen binding adhesin (BabA) mediates bacterial adherence to human blood group antigens on gastric epithelium. Although strains harbouring babA2 were recently found to be associated with peptic ulcer and gastric cancer, the role of babA2 in cellular turnover, severity of gastritis, and premalignant changes is poorly understood. Aim: We correlated H ...
متن کاملThe Role of Helicobacter Pylori Virulence Factors in Gastric Cancer
Introduction: Gastrointestinal (GI) cancers are considered among the most important causes of mortality and morbidity. Helicobacter pylori infection has been proven to be highly associated with the development of a variety of gastric diseases such as chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue (MALT), and gastric cancer (GC). To date, the exact role of the v...
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ژورنال
عنوان ژورنال: Gut
سال: 2003
ISSN: 0017-5749
DOI: 10.1136/gut.52.7.927